Depressive rumination and the C957T polymorphism of the DRD2 gene
نویسندگان
چکیده
منابع مشابه
Depressive rumination and the C957T polymorphism of the DRD2 gene.
Depressed individuals who ruminate have difficulties learning from punishment and suppressing task-irrelevant information. The C957T polymorphism of the DRD2 gene, which affects functioning of D2 dopamine receptors (DRD2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. Given these associations, we ex...
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15 صفحه اولThe C957T DRD2 Polymorphism Predicts Rule-Based Category Learning Performance
We assessed the role of the DRD2 dopaminergic striatal gene polymorphism on performance in unidimensional and conjunctive rule-based category learning tasks. The unidimensional task requires a rule along a single stimulus dimension, while the conjunctive rule task utilizes a combination of two dimensions to distinguish members of each category. The results show that DRD2 C957T T allele carriers...
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Introduction: Schizophrenia is a mental disorder affecting 1% of the world's population. Two of genes have been recognized to be involved in development of this disease: DRD2 and GSTM1. Methods: This case-control study included 100 patients suffering from schizophrenia who referred to Yazd Neuropsychiatry Hospital. Also, 100 healthy patients without schizophrenia were selected as the control g...
متن کاملDRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory pe...
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ژورنال
عنوان ژورنال: Cognitive, Affective, & Behavioral Neuroscience
سال: 2012
ISSN: 1530-7026,1531-135X
DOI: 10.3758/s13415-012-0112-z